Hemodynamic modeling of the cardiovascular system has served as an experimental mainstay for over a century yet limited access to contemporary in-vitro and computational models for the vascular surgeon may soon serve as an impediment to progress as the fidelity of these techniques mature. Such models of the human circulation are of variable complexity from zero-dimensions (0D) to three-dimensions (3D) or a combination thereof, otherwise known as the multi-scale model. We have developed an in-vitro multi-scale, pulsatile, patient-specific method for predicting hemodynamic conditions of the vascular anatomy and permits a detailed study of the pressures and flows generated by any multi-vessel region of interest in the human circulatory system.